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Kenbelt Park, Nairobi, Kenya

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info@kibs.co.ke

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+254 113245615

Outsourec yur clinical trials in Africa

Mass Spectrometry Services

We provide mass spectrometry (MS) services for the identification and quantification of molecules. Mass spectrometry services also aid in the determination of the composition and structure of molecules. In addition, our mass spectrometry services are also useful in the study of interactions and functions. Our mass spectrometry services are useful for the following applications:

Mass Spectrometry Services in Clinical Toxicology

In clinical settings, our mass spectrometry services can detect acute and chronic metal exposure in patients’ blood and urine. Our mass spectrometry services can also identify and quantify drugs and poisons in body fluids and tissues.

Detection of Substances of Abuse

Mass spectrometry is the gold standard for detecting drugs of abuse (DOA) such as bhang (marijuana), heroin, cocaine, hallucinogens and prescription-type drugs used non-medically.

Mass Spectrometry for Food Safety & Quality

Our mass spectrometry services are useful for the detection of pesticides, organic pollutants, pathogens, and drugs in human food. We can also determine the nutritional value of food. Our MS services also map the nutraceutically active compounds in food, and determine the micronutrient and macronutrient profile of food (proteins, lipids, carbohydrates). in addition, our MS services can also map the flavor and sensory quality of food as well as map the pigments in food.

Mass Spectrometry for Proteomics

Our mass spectrometry services aid in:

  • Identification of proteins and their sequences
  • Characterization of the proteome
  • Stoichiometry and conjugation-site characterization of antibody-drug conjugates
  • Identification and quantification of post-translational modifications (PTMs). This includes methylation, acetylation, ubiquitination, and phosphorylation pathway mapping/profiling.
  • Mapping of PEGylation sites, glycosylation sites and site occupancy in host cell protein (HCP) analysis
  • Profiling of phospholipids and lipids
  • Stability studies, forced degradation and degradation studies
  • Mapping of disulfide bonds and , complex glycoproteins, antibodies, glycosaminoglycans (GAGS), heparin, and heparan sulfate
  • Characterization of isoforms and glycan structures

Mass Spectrometry for Metabolomics

Mass spectrometry for metabolomics aids in biomarker discovery and detection of metabolic diseases such as PKU. In pharmaceuticals, metabolomics can provide data on drug toxicity and pharmacokinetics. Mass spectrometry can also be used to assess the toxicity and activity of cosmetics and assist food breeders to improve flavor and other traits. Mass spectrometry can detect metabolites associated with food adulteration and contamination. This can aid in enhancing food safety and quality.

Mass Spectrometry for Forensics

Mass Spectrometry can be used to provide clues on microscopic trace samples left behind by a suspect in crime. Analysis of the scene of crime materials using mass spectrometry can provide information about the sources of clothing and carpet fibers; glass shards; paint; inks; dyes; and even metal.

Mass spectrometry is a useful tool in arson investigations. Investigators can detect accelerants by analyzing lingering odors and burn patterns. Mass spectrometry can then be used to analyze residues, thereby providing an accurate report of the molecular makeup of the residue. This report can identify the presence of distinctive or alien compounds that can be indicative of a serial arsonist if these are present at multiple crime scenes.

Moreover, mass spectrometry can be used to detect poisons, drugs and toxins in human tissue. This can provide clues on how someone died as well as help identify the time and dosage of any poison or medication ingested. Investigators can also determine if a victim was a regular user of any substances that might have contributed to his or her death.

Analysis of explosive residues using mass spectrometry can identify the materials used in explosions and help investigators identify the source of the explosion. This is useful because bomb detonations leave very little physical evidence. Analysis of bomb fragments and chemical residues is thus of importance because commercial explosive manufacturers use their own unique mix of chemicals.

Mass Spectrometry for Drug Development & Research

Mass Spectrometry for Drug Development and Research includes:

  • Target identification
  • Characterization of drug candidates
  • Optimization of drug properties
  • Safety and efficacy testing
  • Pharmacokinetics Studies/ ADMET
  • Post-market surveillance & pharmacovigilance
  • Pharmacognosy – characterization of crude drugs obtained from natural sources such as plants, animals and microbe

    Mass Spectrometry for Environmental Toxicology

    Our mass spectrometry services for environmental toxicology include:

    • Assessment of lead contamination in buildings due to old lead water pipes, lead containing paint, or historic use of gasoline with tetraethyl lead
    • Analysis of Sulphur content in air
    • Screening for the presence of toxic compounds such as chloro-phenols in water and soil
    • Screening for the presence of harmful substances such as polycyclic aromatic hydrocarbons (PAH) and nitro-PAHs, dioxins, dibenzofurans, organo-chlorine pesticides, herbicides, phenols, halogenated pesticides in the environment
    • Analysis of toxic metals such as thallium, arsenic, mercury, lead, chromium, cadmium, platinum, nickel, aluminum, and gadolinium in the environment.

    Contact A Scientist With Your Mass Spectrometry Service Needs.

    We will get back to you within one business day.