Murine bone marrow cells are cells that are derived from the bone marrow of mice. The bone marrow is a soft, spongy tissue found inside the bones, and it is responsible for the production of various types of blood cells. In biomedical research, murine bone marrow cells are widely used as a model system to study hematopoiesis (the process of blood cell formation), immune responses, and various diseases. These cells are obtained from mice through via flushing the bone marrow cavity with a sterile solution or crushing the bones to release the marrow. Once isolated, murine bone marrow cells can be further characterized and manipulated for specific research purposes. 

Murine bone marrow cells consist of a heterogeneous population of cells, including hematopoietic stem cells (HSCs), progenitor cells, and differentiated blood cells. HSCs are multipotent cells that have the ability to self-renew and differentiate into all types of blood cells. They serve as the foundation for hematopoiesis and are crucial for maintaining a constant supply of blood cells throughout an organism’s lifetime. Common application of murine bone marrow cells is in studying the development and function of the immune system. Researchers can isolate specific immune cell populations from the bone marrow, such as B cells, T cells, natural killer (NK) cells, dendritic cells, and macrophages. Murine bone marrow cells are also used in research related to hematological disorders and cancer and in preclinical studies to evaluate the efficacy and safety of potential therapeutic interventions.