SGOT/AST TEST
675 Kshs | Home Collection Available
Synonyms
aspartate aminotransferase, Serum glutamic oxaloacetic transaminase, SGOT, Transaminases
Purpose
The SGOT/AST (Serum Glutamic-Oxaloacetic Transaminase/Aspartate Aminotransferase) test measures the level of AST enzyme in the blood. The liver, heart, muscles, kidneys, and brain all produce AST, but it enters the bloodstream when liver or muscle cells are damaged.
This test plays a critical role in diagnosing liver disorders such as hepatitis, liver cirrhosis, or liver injury due to toxins or medications. It helps healthcare professionals evaluate the extent of liver damage and monitor disease progression or treatment response.
The test can be performed alongside ALT (Alanine Aminotransferase), ALP (Alkaline Phosphatase), Gamma GT, Bilirubin levels, and Liver Function Panel.
Patient Preparation
Does not require any special preparation before testing.
Samples
1ml with a minimum volume of 0.7ml of plasma or serum collected in a Gel-barrier, red-top, or green top tube (lithium heparin). Avoid using EDTA, oxalate, or citrate plasma. Separate the plasma or serum from the cells within 45 minutes of sample collection. Store the samples at room temperature.
Reference Range
Between 8 and 45 units per liter (U/L) of serum
Results Turnaround
Within one day of receipt of samples.
Diseases / Diagnostic indicators
Elevated AST levels often indicate liver damage but can also reflect injury to the heart, muscles, or kidneys. Some possible outcomes of the test include:
High AST levels may suggest:
- Acute or chronic hepatitis
- Liver cirrhosis
- Alcoholic liver disease
- Heart conditions like myocardial infarction
- Muscle disorders such as muscular dystrophy or trauma
- Hemolysis or pancreatitis
- Moderate elevation may appear in non-hepatic conditions like burns, seizures, or strenuous exercise.
- Low or normal levels are generally not clinically significant but can help rule out active tissue damage.
AST is often interpreted alongside ALT levels. A high AST-to-ALT ratio (especially >2:1) may suggest alcoholic liver disease, while a lower ratio is more typical of viral hepatitis or non-alcoholic fatty liver disease (NAFLD).
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