Lipase Test
1,200 Kshs | Home Collection Available
Synonyms
None
Purpose
The Lipase Test measures the level of lipase, an enzyme produced primarily by the pancreas, in the blood. Lipase breaks down dietary fats into fatty acids and glycerol, playing a key role in digestion.
This quantitative blood test reflects how much lipase is circulating, indicating pancreatic enzyme release.
Elevated lipase levels are a sensitive and specific marker for acute pancreatitis and can also rise in chronic pancreatitis, pancreatic pseudocysts, or pancreatic cancer. Early detection through lipase testing allows for prompt management of pancreatic inflammation and prevents serious complications.
The test can be combined with Amylase Test, Liver Function Tests (LFTs), Triglyceride Level, Abdominal Ultrasound or CT Scan, and Complete Blood Count (CBC).
Patient Preparation
The patient should avoid eating or drinking anything other than water for at least 8 hours before the test.
Samples
1ml with a minimum volume of 0.7ml of Serum or plasma collected in a Gel-barrier tube, red-top tube, or green top tube (lithium heparin). Avoid using EDTA, oxalate, or citrate plasma. Plasma or serum should be separated within 45 minutes of sample collection. Store the sample at room temperature.
Reference Range
0-160U/L
Results Turnaround
Within 24 hours of receipt of samples.
Diseases / Diagnostic indicators
The Lipase Test helps confirm pancreatic and abdominal disorders by measuring blood lipase levels. The test results may indicate;
Elevated Lipase Levels
Strongly suggest acute pancreatitis, where pancreatic inflammation causes a rapid enzyme spike. They can also occur in:
- Chronic pancreatitis (though elevations may be more modest)
- Pancreatic pseudocyst formation
- Peritonitis, when inflammation of the peritoneum involves pancreatic irritation
- Pancreatic duct obstruction (e.g., gallstones)
Normal or Slightly Elevated Levels
- May indicate the absence of significant pancreatic inflammation. Mild elevations can sometimes be seen in non‑pancreatic abdominal conditions and warrant clinical correlation.
Trend over Time
- Rising Lipase: Ongoing or worsening pancreatic injury
- Falling Lipase: Resolution of inflammation and effective treatment
Interpreting lipase results alongside clinical presentation, imaging (ultrasound/CT), and other labs (amylase, LFTs, triglycerides) ensures accurate diagnosis and management. For more on Lipase testing, read this study.