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Hepatitis B Surface Ag Test

Hepatitis B Surface Ag Test

Synonyms

Quantitative HBsAg, Quantitative HBV surface antigen, Quantitative Hepatitis B Virus Surface Antigen, HBsAg

Purpose

The Hepatitis B Surface Antigen (HBsAg) Test is a blood test that detects the presence of the hepatitis B surface antigen in the bloodstream. It is commonly prescribed for individuals suspected of having a hepatitis B infection.

Detecting HBsAg is crucial for identifying both acute and chronic hepatitis B infections. Early detection helps prevent liver complications, such as cirrhosis and liver cancer, and reduces the risk of transmission to others. It is also essential for screening blood donors and pregnant women.

The test can be performed alongside Hepatitis B Core Antibody (anti-HBc, Hepatitis B Surface Antibody (anti-HBs), Hepatitis B e Antigen (HBeAg), Liver function tests (ALT, AST), and HBV DNA.

Patient Preparation

The patient should not be taking a biotin supplement for at least 72 hours before sample collection.

Samples

3.5 mL Serum or plasma collected in red-top tube, gel-barrier tube, or lavender-top (EDTA) tube. If the sample is not collected in a gel-barrier tube, separated plasma or serum should be transferred to a plastic transport tube. Samples are stable at room temperature, refrigerated, or frozen for 14 days.

Hepatitis B Surface Ag Test in Kenya

Reference Range

Negative

Results Turnaround

1-2 days after sample collection.

Diseases / Diagnostic Indicators

A positive HBsAg test indicates that the person is currently infected with the hepatitis B virus, either in the acute or chronic stage. This means the virus is present in the blood, and the individual can potentially transmit the infection to others.

People with a positive result may experience symptoms such as:

  • Dark urine
  • Fever
  • Joint pain
  • Loss of appetite
  • Nausea and vomiting
  • Weakness and fatigue
  • Yellowing of the skin or eyes (jaundice)

A negative HBsAg result usually means there is no active hepatitis B infection, but additional testing (like anti-HBs or anti-HBc) may be needed to confirm immunity or past exposure. For more on the Hepatitis B Surface Ag Test, read this study.