CA-125 Test
2,100 Kshs | Home Collection Available
Synonyms
Cancer antigen 125, tumor marker, ovarian cancer
Purpose
The CA 125 test measures the level of cancer antigen 125, a protein that is often elevated in the blood of individuals with certain cancers. It is primarily used to help diagnose, monitor, or evaluate treatment response in ovarian cancer, as well as primary peritoneal and fallopian tube cancers.
CA 125 is a tumor marker, and tracking its levels over time can:
- Help detect ovarian cancer early (especially in high-risk individuals)
- Monitor how well a patient is responding to treatment
- Identify recurrence after remission
- Assist in distinguishing between benign and malignant pelvic masses
Other tests that can be performed alongside ca 125, Transvaginal ultrasound (TVUS), pelvic exam, HE4 test, CBC, CT scan or MRI, CEA, BRCA1 and BRCA2 genetic testing. Together, these tests provide a more accurate assessment and guide treatment planning.
Patient Preparation
No preparation is necessary before the CA-125 test.
Samples
5 ml of serum collected in a red top tube or gel barrier tube. Transfer the separated serum to a plastic transport tube if a red-top tube is used. Store the sample at room temperature.
Reference Range
Female, 0.0-38.1 units/ml
Results Turnaround
Within 24 hours of receipt of samples.
Diseases / Diagnostic indicators
CA 125 is commonly associated with ovarian carcinoma, but elevated levels can also occur in a variety of non-cancerous and cancerous conditions. Here are the possible outcomes of the test,
Elevated CA 125 levels
- Ovarian cancer (especially in postmenopausal women)
- Other cancers: fallopian tube, endometrial, pancreatic, breast, or lung
- Benign conditions: endometriosis, ovarian cysts, uterine fibroids, liver disease, cervicitis, pregnancy, and menstruation
- Inflammatory conditions: pelvic inflammatory disease (PID)
An elevated result alone is not diagnostic of cancer,further testing and clinical correlation are required.
Normal CA 125 levels
- May indicate no current abnormal activity or cancer
However, early-stage ovarian cancer can sometimes present without elevated CA 125, especially in premenopausal women
Fluctuating or declining levels
- Persistent or rising levels may suggest recurrence or progression
- May show response to treatment or remission