Total Iron Binding Capacity Test
2,400 Kshs | Home Collection Available
Synonyms
TIBC and iron, total iron binding capacity, transferrin saturation, TIBC
Purpose
The Total Iron-Binding Capacity (TIBC) Test measures the blood’s capacity to bind and transport iron. It indirectly reflects the level of transferrin, the main protein that binds iron in the bloodstream.
This test is important for assessing iron status and helps diagnose conditions like iron deficiency anemia or iron overload disorders such as hemochromatosis. It provides insight into how much iron is available in the body and how well it’s being transported.
The test can be performed alongside Serum Iron, Transferrin, Transferrin Saturation, Ferritin, and Complete Blood Count (CBC). Together, these tests give a comprehensive view of iron metabolism and help identify the cause of iron imbalances.
Patient Preparation
The sample should be collected before blood transfusion or therapeutic iron administration.
Samples
2ml with a minimum volume of 0.7ml of serum or plasma collected in a Gel-barrier, red-top, or green top tube (lithium heparin). Avoid using EDTA, oxalate, or citrate plasma. Separate the serum or plasma within 45 minutes of sample collection. Store the sample at room temperature.
Reference Range
255-450µg/dl
Results Turnaround
Within 24 hours after sample collection.
Diseases / Diagnostic indicators
Clinicians use the TIBC test to assess how well the body transports iron and to diagnose iron-related disorders.
High TIBC levels may suggest:
- Iron deficiency anemia – the body increases transferrin production to capture more iron
- Pregnancy – increased transferrin is normal
- Use of oral contraceptives can raise transferrin levels
Low TIBC levels may indicate:
- Hypoproteinemia – low protein levels due to malnutrition, liver disease, or kidney disorders
- Chronic illnesses or inflammation, which can reduce transferrin production
- Hemochromatosis – iron overload reduces the need for iron-binding capacity
Clinicians interpret Total Iron Binding Capacity (TIBC) Test results alongside serum iron, ferritin, and transferrin saturation to determine the cause of abnormal iron levels and guide treatment decisions. For more on TIBC, read this study.