ESTRADIOL (E2) TEST
1,500 Kshs | Home Collection Available
Synonyms
E2, Oestradiol, Estradiol, Fertility
Purpose
The Estradiol (E2) Test measures the level of estradiol, a form of estrogen, in the blood. This E2 test is essential for assessing ovarian function, evaluating menstrual irregularities, diagnosing fertility issues, and monitoring hormone therapy. It also helps detect conditions like polycystic ovary syndrome (PCOS), early or delayed puberty, and menopausal status.
For a more comprehensive diagnosis, the Estradiol Test is often combined with other hormone tests such as the Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) tests. Together, these tests give a clearer picture of reproductive health and hormonal balance in both women and men.
Patient Preparation
The patient should avoid taking biotin supplements for at least 72 hours before sample collection.
Samples
1ml with a minimum volume of 0.7ml of serum or plasma collected in a Gel-barrier, red-top, or green top tube (lithium heparin). Avoid using EDTA, oxalate, or citrate plasma. Transfer separated serum to a plastic transport tube if a red top tube is used. Store the sample at room temperature.
Reference Range
Adult male: 7.6-42.6pg/ml, adult female:12.5-498.0pg/ml, children 0.0-27.0pg/ml
Results Turnaround
Within 24 hours after sample collection.
Diseases / Diagnostic indicators
Estradiol levels vary depending on age, sex, and reproductive status. Interpreting these levels can help identify or monitor several health conditions:
- Elevated levels of Estradiol (E2) test may indicate:
- Multiple pregnancy (e.g., twins or more)
- Hormone-secreting tumors such as chorionic carcinoma
- Certain ovarian or adrenal gland tumors
- Low estradiol levels may suggest:
- Ectopic pregnancy
- Gestosis (a complication of pregnancy involving high blood pressure)
- Missed abortion (when fetal death occurs without expulsion)
- Menopause or premature ovarian failure
- Hypopituitarism (low pituitary function)
Because estradiol plays a key role in regulating the menstrual cycle and supporting pregnancy, its levels are commonly assessed during fertility evaluations, pregnancy monitoring, and hormone therapy.