Alpha Thalassemia (Hemoglobin Disorder-Var- Hb)

Alpha thalassemia is a blood disorder that reduces the production of hemoglobin.

Signs and Symptoms
This disorder causes a shortage of red blood cells (anemia), which can cause pale skin, weakness, fatigue, along with other complications. Two types have been observed: (I) Hb Bart: characterized by severe anemia, enlarged liver and spleen, heart defects, abnormalities of urinary system or genitalia. (II) HbH: Characterized by mild to moderate anemia, jaundice, overgrowth of jaw or prominent forehead. This disorder can also be caused by mutations in the HBA1 gene.


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